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Sildenafil
Clinical data
Pronunciation/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil
Trade namesViagra, Revatio, others
AHFS/Drugs.comMonograph
MedlinePlusa699015
License dataEU  EMA:  by INN, US   FDA: Sildenafil
Pregnancy categoryAU: B1 US: B (No risk in non-human studies)
Routes of administrationBy mouth (tablets), IV
ATC codeG04BE03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: P (Pharmacy medicines) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability41% (mean) [1]
Protein binding~96%
MetabolismLiver: CYP3A4 (major route), CYP2C9 (minor route)
MetabolitesN -desmethylsildenafil (~50% potency for PDE 5 )
Elimination half-life3–4 hours
ExcretionFeces (~80%), urine (~13%) [2]

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Specific Populations: Consider a starting dose of 25 mg of VIAGRA for patients age 65, patients with hepatic impairment, or severe renal impairment. Consider a starting dose of 25 mg of VIAGRA with erythromycin or strong CYP3A4 inhibitors eg, ketoconazole, itraconazole, saquinavir Decreased blood pressure, syncope, and prolonged erection may occur at higher sildenafil exposures.

Sexually Transmitted Diseases: Use of VIAGRA offers no protection against sexually transmitted diseases, including the human immunodeficiency virus HIV therefore, physicians should consider counseling their patients about protective measures.

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