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Advise patients not to abruptly discontinue trazodone hydrochloride tablets and to discuss any tapering regimen with their healthcare provider. Adverse reactions can occur when trazodone hydrochloride tablets are discontinued see Warnings and Precautions 5.

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Is desyrel safe metabolic pathways that may be involved in the metabolism of trazodone have not been well characterized. Peak plasma levels occur approximately one hour after dosing when trazodone hydrochloride is taken on an empty stomach trazodone is metabolized, via oxidative cleavage, to an active metabolite, mchlorophenylpiperazine mCPP by CYP3A4.

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