Simvastatin may harm an unborn baby. Therefore, it is important to prevent pregnancy while taking this medication. Zocor (simvastatin) pkge. 10 mg 10 amount of packaging.
UbMed: 3469684Elsby R, Hilgendorf Zocor 40 mg tablet, Fenner K: Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: it's not just about OATP1B1.
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Lose clinical monitoring of such patients taking this combination is advised. There have been reports of myopathy and rhabdomyolysis with the concomitant administration of colchicine and simvastatin in patients with renal impairment. difference between crestor and simvastatin
|Pronunciation||/ ˈ s ɪ m v ə s t æ t ɪ n /|
|Trade names||Zocor, other|
|License data||EU EMA: by INN, US FDA: Simvastatin|
|Pregnancy category||AU: D US: X (Contraindicated)|
|Routes of administration||by mouth|
|ATC code||C10AA01 ( WHO )|
|Legal status||AU: S4 (Prescription only) UK: P (Pharmacy medicines) when ≤10 mg/day, POM when >10 mg/day., US: ℞-only|
|Elimination half-life||2 hours for simvastatin and 1.9 hours for simvastatin acid|
|Excretion||Renal 13%, faecal 60%|
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Clin Transplantation. A double-blind placebo controlled trial of simvastatin for the treatment of dyslipidaemia in renal allograft recipients.
Skip the missed dose if it is almost time for your next scheduled dose. Take the missed dose as soon as you remember.Zocor alternative product:
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Years with heterozygous familial hypercholesterolaemia HeFH were randomised to simvastatin or placebo for 24 weeks base study Inclusion in the study required a baseline LDL-C level between 160 and 400 mg/dL and at least one parent with an LDL-C level 189 mg/dL. and 47% respectively. In studies of patients with combined mixed hyperlipidaemia on simvastatin 40 mg and 80 mg, the median reductions in triglycerides were 28 and difference between zocor and crestor placebo: 2% respectively, and mean increases in HDL-C were 13 and 16% placebo: 3% respectively, diltiazem hcl er tz.
The dosage of simvastatin once daily in the evening was difference between zocor and crestor mg for the first 8 weeks, 20 mg for the second 8 weeks, and 40 mg thereafter. In a double-blind, placebo-controlled study, 175 patients 99 boys Tanner Stage II and above and 76 girls who were at least one year post-menarche 10-17 years of age mean age 14.
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S a rare and serious condition that may be inherited genetic People with homocystinuria die at an early age. Symptoms of hyperhomocysteinemia include developmental delays, osteoporosis, blood clots, heart attack, heart disease, stroke, and visual abnormalities. 40 mg zocor the diet with folic acid and possibly vitamins B6 and B12 supplements can lower homocysteine levels.
There are other causes of hyperhomocysteinemia, for example, alcoholism. imes per day, pumpinga total of five or six quarts of blood each minute, or about 2, 00 gallons per day. Elevated homocysteine levels in the 40 mg zocor called hyperhomocysteinemia, is a sign that the body isn't producing enough of the amino acid homocysteine.
For bestresults in lowering your cholesterol, it is very important that you closelyfollow the diet suggested by your doctor. Themaximum dose for children and adolescents 10 to 17 years of age with inheritedcholesterol disorders is 40 mg.
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Zocor 40 mg tablet ubMed: 5601807Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. J Clin Pharmacol. Biopharm Drug Dispos. 2005 Jan; 1 68-78.
OATP1B pathways may increase simvastatin and simvastatin acid plasma concentrations and may lead to an increased risk of myopathy/rhabdomyolysis. Drugs or herbal products that inhibit certain enzymes e. Consult difference between crestor and simvastatin prescribing information of all concomitantly used drugs to obtain further information about their potential interactions with simvastatin and/or the potential for enzyme or transporter alterations and possible adjustments to dose and regimens.
CYP3A4 and/or transporter e.
- And 4. Rare cases of myopathy/rhabdomyolysis have been associated with simvastatin co-administered with lipid-modifying doses (1 g/day) of niacin (nicotinic acid) In a pharmacokinetic study, the co-administration of a single dose of nicotinic acid prolonged-release 2 g with simvastatin 20 mg resulted in a modest increase in the AUC of simvastatin and simvastatin acid and in the Cmax of simvastatin acid plasma concentrations. Concomitant administration of medicinal products that are inhibitors of BCRP, including products containing elbasvir or grazoprevir, may lead to increased plasma what is the difference between crestor and simvastatin of simvastatin and an increased risk of myopathy (see what is the difference between crestor and simvastatin 4.
- Monitor LFTs before initiating treatment compare crestor to simvastatin thereafter when clinically indicated; reports of fatal and nonfatal compare crestor to simvastatin failure in people taking statins. Discontinue if markedly elevated CPK levels occur or myopathy is diagnosed or suspected. itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, posaconazole, voriconazole, HIV protease inhibitors, cobicistat, nefazodone, boceprevir, telaprevir) gemfibrozil, cyclosporine, and danazol Increased blood sugar and glycosylated hemoglobin (HbA1c) levels reported with statin intake.
- Difference between crestor and simvastatin ZOCOR (simvastatin) is a lipid-lowering agent that is derived synthetically from a fermentation product of Aspergillus terreus. After oral ingestion, simvastatin, which is an inactive lactone, is hydrolyzed to the corresponding -hydroxyacid form. You may report side effects to FDA at 1-800-FDA-1088.
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- Furthermore, this approach simplifies treatment guidelines and potentially will increase treatment rates in this high-risk group. 0 mmol/l) This approach is supported by evidence showing that all diabetic patients are in the highest risk category, difference between crestor and simvastatin the difference between crestor and simvastatin of those considered at lower risk, mostly younger individuals, will attain a risk of 20% over a 20-year period. This seemingly aggressive approach is also justified because primary prevention of cardiovascular complications in diabetic patients is essential because of the high case-fatality rates among individuals who develop cardiovascular complications.
Most people with high cholesterol or triglycerides do not feel sick. Remember 40 mg zocor take it at the same time each day. Keep taking this medication even if you feel well.
All your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. You may report side effects to FDA at 1-800-FDA-1088. Call your doctor for medical advice about side effects. In difference between crestor and simvastatin cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure.
liver problems--loss of appetite, stomach pain upper right side tiredness, itching, dark urine, clay-colored stools, jaundice yellowing of the skin or eyes This is not a complete list of side effects and others may occur. Get emergency medical help if you have signs of an difference between crestor and simvastatin reaction: ives; difficult breathing; swelling of your face, lips, tongue, or throat.
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Remember that your doctor crestor 20mg vs zocor prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. It is very important to continue to follow your doctor's advice about diet and exercise. It may take up to 4 weeks before you get the crestor 20mg vs zocor benefit of this drug. Keep taking this medication even if you feel well.
Most people with high cholesterol or triglycerides do not feel sick.
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Supplementary information. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
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In this case, symptomatic and supportive measures should be adopted. There is no specific treatment in the event of overdose.
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See Specific Drugs and Foods under Interactions. Concomitant use with potent CYP3A4 inhibitors e. Active liver disease, including unexplained, persistent elevations of serum aminotransferases. itraconazole, ketoconazole, posaconazole, voriconazole, HIV protease inhibitors, compare crestor to simvastatin, erythromycin, telithromycin, nefazodone, cobicistat-containing preparations gemfibrozil, cyclosporine, or danazol.
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The incidence of adenomas of the liver was significantly increased in mid- and high-dose females. nd 400 mg/kg body weight, which resulted in mean plasma drug levels approximately 1, 4, and 8 times higher than the mean human plasma drug level, respectively as total inhibitory activity based on AUC after an 80-mg oral dose. Compare crestor to simvastatin carcinomas were significantly increased in high-dose females and mid- and high-dose males with a maximum incidence of 90% in males.
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Postapproval use compare crestor to simvastatin simvastatin: pruritus, alopecia, a variety of skin changes e. Multiracial with heterozygous familial respiratory infection, headache, abdominal pain, and nauseasee Use In Specific a population of uncertain size, it is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
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Use a marked measuring spoon, oral syringe, or medicine cup to measure the right dose. Shake the oral suspension well for at least 20 seconds before using it.
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Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed and zocor muscle cramps. Keep all medications away from children and pets. Discard the suspension form difference between zocor and crestor this medication one month after opening the bottle, even if there is medication left.
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It can be harmfulfor people to take this medication if their doctor has not prescribed it. Each peach-coloured, oval, biconvex, film-coated tablet, engraved MSD 735 on one side and plain on the other, contains10 mg of simvastatin. Donot give this medication to anyone else, even if they have the same symptoms asyou do. ...
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03 Use with caution, since age 65 years is a predisposing factor for myopathy. In patients 75 years of age, consider benefits, adverse effects, drug interactions, and patient preferences before initiating statin therapy. 50 Simvastatin/ezetimibe fixed combination: No overall differences in safety or efficacy relative to younger patients; however, increased sensitivity cannot be ruled out. ...
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